** Shares of Madrigal Pharmaceuticals rise as much as 17.4% to a two-month high of $253.55

** Stock set for its best day since Dec 2022, if gains hold

** Drugmaker's Q3 rev from its sole product, fatty liver drug Rezdiffra, is $62.2 mln, beating Wall Street estimates of $34.2 mln - LSEG

** Fatty liver disease, known as metabolic dysfunction-associated steatohepatitis (MASH), affects around 5% of the U.S. population. The condition was earlier called non-alcoholic steatohepatitis (NASH)

** "This represents a second consecutive quarter of strong launch execution that increases our conviction in the underlying patient/prescriber demand" - Brokerage Leerink Partners

** MDGL has been able to successfully leverage its first-mover advantage and commercial experience to build the NASH market opportunity - Leerink

** In March, Rezdiffra became the first drug for the condition to be approved by the U.S. FDA

** YTD, stock up 8.1%

(Reporting by Puyaan Singh)

((Puyaan.Singh@thomsonreuters.com;))