金吾财讯 | 康宁杰瑞制药(09966)午后一度涨超16%，截至发稿，涨6.69%，报3.67港元，成交额3718万港元。消息面上，公司公布，JSKN003获中国国家药品监督管理局药品审评中心同意开展一项III期临床研究。据悉，JSKN003是一种靶向HER2双表位ADC，其通过糖基定点偶联技术将拓扑异构酶I抑制剂连接至抗体KN026(重组人源化抗HER2双特异性抗体)的N糖基化位点处。点击反应偶联物较马来酰亚胺－迈克尔反应的偶联物具有更好的血清稳定性。双表位HER2靶向性使JSKN003具有更强的内吞诱导及旁观者杀伤效应，使其在HER2表达肿瘤中具有较强的抗肿瘤活性。目前，JSKN003正在澳大利亚开展I期临床研究，在中国进行I/II期和III期临床研究。
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