金吾财讯 | 兆科眼科(06622)公告，TAB014（公司核心候选药物之一）用于治疗湿性（新生血管）老年黄斑部病变（“wAMD”）第III期临床试验的积极顶线结果。该项临床试验成功达到主要终点及关键次要终点。TAB014的第III期临床试验为一项随机、双盲及非劣效性研究，主要目标为评估接受TAB014治疗的对象群组对比接受Lucentis®治疗的对象群组于第52周的最佳矫正视力(BCVA)的基线值变化。该项研究涉及约57间中心，入组合共488名患者，由北京协和医院的陈有信教授出任牵头主研究者。TAB014（重组人源化抗血管内皮细胞生长因子（“VEGF”）单克隆抗体）为基于贝伐单抗的眼科制剂，为治疗wAMD而开发。wAMD的主要病理学特征为黄斑部脉络膜血管生成，而VEGF在血管生成过程中起着重要作用。TAB014能够与VEGF特异性结合，并阻止其与受体结合，从而抑制血管生成。TAB014将最终透过玻璃体腔内注射给药，治疗wAMD。
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