智通财经APP获悉，3月24日，阿斯利康(AZN.US)宣布重度嗜酸粒细胞性哮喘(SEA)创新靶向生物制剂凡舒卓®(通用名:本瑞利珠单抗注射液)在中国正式商业上市，用于成人和12岁及以上青少年重度嗜酸粒细胞性哮喘的维持治疗。
本瑞利珠单抗是精准靶向嗜酸性粒细胞(EOS)的抗IL-5R创新生物制剂。一项汇总分析研究，在基线bEOS≥300/μL的患者中，与安慰剂组相比，本瑞利珠单抗治疗3天后即可快速改善哮喘症状。PONENTE及SHAMAL研究显示，与基线相比，超90%的重度哮喘患者减少口服糖皮质激素(OCS)及吸入激素(ICS-福莫特罗)使用，长期治疗安全性良好。
阿斯利康中国副总裁，呼吸和自体免疫生物制药、疫苗及免疫疗法事业部负责人陈曦表示：“非常高兴看到本瑞利珠单抗在中国成功上市，这是阿斯利康在呼吸领域的首款生物制剂，也标志着中国重度哮喘的治疗步入了精准靶向治疗时代。目前我们在中国上市的产品涵盖了哮喘轻中度到重度的完整产品组合和解决方案，满足了不同分型哮喘患者全病程管理的需求。未来，我们也将持续加速引入创新药物，为患者提供更加个性、精准化的治疗服务。”
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