创胜集团-B(06628.HK) 公布，于2025年美国癌症研究协会年会(AACR)上公布，基于新型人源化FGFR2b抗体的ADC(TST105)的最新临床前研究结果。该ADC采用糖基转移酶介导的定点偶联技术，搭载新型拓扑异构酶I抑制剂作为有效载荷，在临床前胃癌和结直肠癌模型中，相比以MMAE为载荷的ADC，展现出显著增强的抗肿瘤活性。
据体外实验数据显示，TST105具有显著的内化作用、特异性杀伤活性及旁观者杀伤效应。在胃癌与结直肠癌模型中，TST105表现出优异的体内肿瘤杀伤效果，这可能得益于其定点偶联技术。
创胜集团研发部高级副总裁顾怡表示，随着TST105进入临床开发阶段，集团将全力推动上述候选药物转化为惠及全球患者的突破性疗法。(js/w)
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