** Medical equipment maker Hologic's HOLX.O shares fall as much as 7.6% to a four-year low of $52.94

** HOLX cut its annual profit forecast late on Thursday in the range of $4.15 to $4.25 per share, compared with its previous forecast of $4.25 to $4.35, citing uncertainty around the tariffs

** Company maintains its annual revenue forecast between $4.05 billion and $4.1 billion vs estimates of $4.07 billion - data compiled by LSEG

** HOLX posts Q1 adj. profit of $1.03 per share, slightly beating analysts' estimates of $1.02 per share

** HOLX expects macro dynamics to impact demand in China

** Brokerage BTIG says it does not see meaningful drivers for accelerated growth over the next few quarters

** "Co also left the door open to higher component costs from suppliers, a worry that likely limits investor appetite" - BTIG

** As of last close, HOLX had fallen 26.4% YTD

(Reporting by Siddhi Mahatole)

((siddhi.mahatole@thomsonreuters.com))