智通财经APP获悉，5月6日，基石药业(02616)，一家专注于抗肿瘤药物研发的创新驱动型生物医药企业，宣布公司在2025年美国癌症研究协会(AACR)年会上，以壁报形式公布研发管线2.0重磅产品CS2009(PD-1/VEGF/CTLA-4三特异性抗体)的临床前研究结果。目前，CS2009全球多中心I期临床研究正在澳大利亚进行中，并已于今年3月完成首例患者给药，后续将扩展至中国和美国。
在肿瘤免疫治疗领域，PD-1、VEGFA和CTLA-4是经临床验证的有效靶点，三者间的协同机制可实现多维度的抗肿瘤效应。抗PD-1与CTLA-4双重阻断已在包括非小细胞肺癌(NSCLC)在内的多种肿瘤类型中显示出协同效应，可显著提升患者的总生存期(OS)和无进展生存期(PFS)获益。若进一步联合阻断VEGFA信号通路，其疗效有望得到更深度强化。CS2009通过在同一分子结构中整合以上三种作用机制，将有望超越现有PD-(L)1单抗、PD-(L)1/VEGF双抗及PD-(L)1/CTLA-4双抗、为患者提供更优的临床获益。
CS2009是一款同时靶向PD-1/VEGFA/CTLA-4三特异性抗体，在实体瘤治疗领域具有广阔的临床应用前景。有望替代现有以PD-(L)1为基础的疗法，成为下一代肿瘤免疫骨架产品。
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