U.S. stock indexes were mixed on Wednesday ahead of the Federal Reserve's interest-rate decision, while a steep decline in shares of Google-parent Alphabet weighed on the Nasdaq. .N

At 13:30 EDT, the Dow Jones Industrial Average .DJI was up 0.89% at 41,191.09.The S&P 500 .SPX was up 0.41% at 5,629.83, and the Nasdaq Composite .IXIC was remained unchanged at 17,689.26.

The top three S&P 500 .PG.INX percentage gainers:

** Charles River Laboratories International CRL.N, up 17.7%

** Rockwell Automation Inc ROK.N, up 12.2%

** Walt Disney Co DIS.N, up 10.8%

The top three S&P 500 .PL.INX percentage losers:

** Dayforce Inc DAY.N, down 8.1%

** Alphabet Inc GOOG.OQ, down 7.6%

** Alphabet Inc GOOGL.OQ, down 7.4%

The top three NYSE .PG.N percentage gainers:

** Flotek Industries Inc FTK.N, up 36.4%

** GrafTech International Ltd EAF.N, up 30.5%

** Oscar Health Inc OSCR.N, up 28.9%

The top three NYSE .PL.N percentage losers:

** Vestis Corp VSTS.N, down 37.9%

** B&G Foods Inc BGS.N, down 26.4%

** agilon health inc AGL.N, down 23.9%

The top three Nasdaq .PG.O percentage gainers:

** Asset Entities Inc ASST.OQ, up 214.2%

** DevvStream Corp DEVS.OQ, up 69.2%

** Porch Group Inc PRCH.OQ, up 64.7%

The top three Nasdaq .PL.O percentage losers:

** Digital Ally Inc DGLY.OQ, down 89.0%

** Vast Renewables Ltd VSTE.OQ, down 59.2%

** Hain Celestial Group Inc HAIN.OQ, down 49.1%

** Sanofi SA <SNY.O>:BUZZ - Drops as FDA names agency critic as top vaccine official nL8N3RF0US

** WW International Inc <WW.O>:BUZZ - Falls after filing for chapter 11 bankruptcy nL6N3RF0DB

** Newmont Corp <NEM.N>:

** Barrick Gold Corp <GOLD.N>:

** Gold Fields Ltd <GFI.N>:

** AngloGold Ashanti PLC <AU.N>:

BUZZ - Gold miners down as bullion prices slip on US-China trade talk hopes nL4N3RF0W7

** Walt Disney Co <DIS.N>:BUZZ - Rises on Q2 results beat nL4N3RF16U

** NovaGold Resources Inc <NG.N>:BUZZ - Falls on planned stock offering nL4N3RF0WO

** Zeekr Intelligent Technology Holding Ltd <ZK.N>:BUZZ - Gains on take-private offer from Geely Auto nL6N3RF0JB

** Sarepta Therapeutics Inc <SRPT.O>:BUZZ - Falls after 2025 product revenue forecast cut, top vaccine official appointment nL4N3RF0ZO

** Charles River Laboratories International Inc <CRL.N>:BUZZ - Rises after settlement with activist investor Elliott, 2025 forecast raise nL4N3RF19Q

** Vestis Corp <VSTS.N>:BUZZ - Shares plunge on pulling FY guidance, Q2 rev miss nL4N3RF11B

** Ford Motor Co <F.N>:BUZZ - CitiGroup raises Ford PT on expected $2.8 billion operating cash surplus nL4N3RF13N

** Emerson Electric Co <EMR.N>:BUZZ - Up after Q2 beat, lifting annual outlook nL4N3RF14X

** CrowdStrike Holdings Inc <CRWD.O>:BUZZ - To layoff about 5% of its workforce; shares down nL4N3RF1QS

** Honeywell International Inc <HON.O>:BUZZ - Rises after BofA upgrades rating on Q1 earnings nL4N3RF11X

** Hain Celestial Group Inc <HAIN.O>:BUZZ - Eyes its worst day on record after annual sales forecast cut; CEO steps down nL6N3RF0JD

** Bunge Global SA <BG.N>:BUZZ - Gains on Q1 profit beat nL4N3RF151

** Entegris Inc <ENTG.O>:BUZZ - Falls as downbeat Q2 forecasts highlight tariff risks nL6N3RF0GB

** Rockwell Automation Inc <ROK.N>:BUZZ - Jumps after raising 2025 pro nL4N3RF18B

** Illinois Tool Works Inc <ITW.N>:BUZZ - Falls after BofA cuts rating on tariff headwinds nL4N3RF126

** Wynn Resorts Ltd <WYNN.O>:BUZZ - Rises after BofA upgrades rating to 'buy' nL4N3RF19F

** GEO Group Inc <GEO.N>:BUZZ - Dips after Q1 results, 2025 EPS forecast disappoint nL6N3RF0GQ

** Tripadvisor Inc <TRIP.O>:BUZZ - Rises after Q1 results beat estimates nL4N3RF1QP

** Marriott International Inc <MAR.O>:BUZZ - BMO raises PT on Marriott after Q1 results top estimates nL4N3RF1AH

** AvidXchange Holdings Inc <AVDX.O>:BUZZ - Rises on $2.2 billion buyout deal with TPG, Corpay nL6N3RF0G8

** BorgWarner Inc <BWA.N>:BUZZ - Rises after lifting annual sales forecast nL4N3RF1B1

** Payoneer Global Inc <PAYO.O>:BUZZ - Slides after suspending 2025 outlook nL4N3RF1C4

** Marvell Technology Inc <MRVL.O>:BUZZ - Slides after chipmaker's investor day postponement nL6N3RF0HV

** Southern Copper Corp <SCCO.N>:

** Freeport-McMoRan Inc <FCX.N>:

** Ero Copper Corp <ERO.N>:

** Hudbay Minerals Inc <HBM.N>:

BUZZ - Copper miners fall on upcoming US-China trade talks optimism nL4N3R21C7

** Leidos Holdings Inc <LDOS.N>:BUZZ - Truist raises Leidos PT after Q1 earnings beat estimates nL4N3RF1E4

** Asset Entities Inc <ASST.O>:BUZZ - Soars on deal to emulate Strategy's bitcoin playbook nL4N3RF1EL

** International Money Express Inc <IMXI.O>:BUZZ - Slides on annual forecast cut nL4N3RF16G

** Bio-Techne Corp <TECH.O>:BUZZ - Rises on Q3 profit beat nL6N3RF0I7

** Icahn Enterprises LP <IEP.O>:BUZZ - Dips after wider Q1 loss nL4N3RF1FF

** Edgewell Personal Care Co <EPC.N>:BUZZ - Plunges on annual forecast cuts nL6N3RF0IC

** Elanco Animal Health Inc <ELAN.N>:BUZZ - Gains on Q1 beat, raised forecast nL4N3RF1EQ

** Steve Madden Ltd <SHOO.O>:BUZZ - Rises after quarterly earnings beat nL6N3R80Q5

** Coty Inc <COTY.N>:BUZZ - Slips after annual profit forecast cut on tariff woes nL6N3RF0IN

** Johnson Controls International PLC <JCI.N>:BUZZ - Rises after lifting 2025 profit forecast nL4N3RF1QT

** Uber Technologies Inc <UBER.N>:BUZZ - Retreats after Q1 rev misses expectations nL6N3RF0JZ

** Cencora Inc <COR.N>:BUZZ - Up on raising 2025 profit forecast nL6N3RF0K7

** Upstart Holdings Inc <UPST.O>:BUZZ - Slides after Q2 forecast fails to impress investors nL6N3RF0JG

** Devon Energy Corp <DVN.N>:BUZZ - Falls after Q1 profit miss nL4N3RF1S3

** Lantheus Holdings Inc <LNTH.O>:BUZZ - Plummets after 2025 forecast, Q1 results miss estimates nL4N3RF1VUx

** Tempus AI Inc <TEM.O>:BUZZ - Rises after Q1 results, annual rev outlook surpass estimates nL6N3RF0LX

** Apple Inc <AAPL.O>:

** Alphabet Inc <GOOGL.O>:

BUZZ - Down after report of iPhone maker exploring adding AI search to browser nL4N3RF1XB

** EQT Corp <EQT.N>:

** Cheniere Energy Inc <LNG.N>:

** Energy Transfer LP <ET.N>:

** United States Natural Gas Fund LP <UNG.N>:

BUZZ - Natgas companies gain on lower output, higher demand nL4N3RF1YE

** Perrigo Company PLC <PRGO.N>:BUZZ - Rises on Q1 profit beat nL4N3RF1YC

(Compiled by Rajarshi Roy and Anshuman Tripathy)

((Rajarshi.Roy@thomsonreuters.com))