Rhythm Pharmaceuticals Set to Submit Supplemental New Drug Application for Setmelanotide in Treating Acquired Hypothalamic Obesity, Following Promising Phase 3 Results

Reuters
14 May
Rhythm Pharmaceuticals Set to Submit Supplemental New Drug Application for Setmelanotide in Treating Acquired Hypothalamic Obesity, Following Promising Phase 3 Results

Rhythm Pharmaceuticals Inc., a global commercial-stage biopharmaceutical company, has announced significant progress in its regulatory review process. The company remains on track to submit a supplemental New Drug Application to the U.S. Food and Drug Administration (FDA) and a Type II variation request to the European Medicines Agency for its drug, setmelanotide, targeted at treating patients with acquired hypothalamic obesity. This follows the successful achievement of the primary endpoint in a pivotal Phase 3 trial, which demonstrated a -19.8% placebo-adjusted BMI reduction in 120 patients. Additionally, Rhythm Pharmaceuticals is anticipated to complete enrollment in a Phase 3 trial substudy investigating the use of setmelanotide in congenital hypothalamic obesity by the second half of 2025.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Rhythm Pharmaceuticals Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9451253-en) on May 14, 2025, and is solely responsible for the information contained therein.

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