European equities traded in the US as American depositary receipts were edging lower late Wednesday morning, down 0.3% at 1,413.61 on the S&P Europe Select ADR Index.

From continental Europe, the gainers were led by biopharmaceutical company DBV Technologies (DBVT) and semiconductor company Sequans Communications (SQNS), which climbed 15% and 9.8% respectively. They were followed by accommodations booking company trivago (TRVG) and financial services company Banco Bilbao Vizcaya Argentaria (BBVA), which increased 3.7% and 1.6% respectively.

The decliners from continental Europe were led by furniture maker Natuzzi (NTZ) and biopharmaceutical company Grifols (GRFS), which dropped 4.6% and 3.4% respectively. They were followed by telecommunications operator Telefonica (TEF) and pharmaceutical company Ascendis Pharma (ASND), which lost 2.3% and 1.7% respectively.

From the UK and Ireland, the gainers were led by biopharmaceutical company NuCana (NCNA) and biotech firm Trinity Biotech (TRIB), which advanced 25% and 5.9% respectively. They were followed by biopharmaceutical company Adaptimmune Therapeutics (ADAP) and financial services company Lloyds Banking Group (LYG), which were up 3.2% and 1.7% respectively.

The decliners from the UK and Ireland were led by software firm Endava (DAVA) and biotech company Autolus Therapeutics (AUTL), which fell 27% and 3.5% respectively. They were followed by biopharmaceutical companies Mereo BioPharma Group (MREO) and Amarin (AMRN), which were down 3.2% and 1.5% respectively.