智通财经APP获悉，今日，艾伯维(ABBV.US)宣布，美国FDA已加速批准旗下抗体偶联药物(ADC)Emrelis(telisotuzumab vedotin，teliso-V)上市，用于治疗具有高c-Met蛋白过度表达(OE)的局部晚期或转移性非鳞状非小细胞肺癌(NSCLC)成年患者，这些患者此前已接受过系统性治疗。高c-Met蛋白过度表达被定义为：经FDA批准的检测方法确定，≥50%的肿瘤细胞显示强阳性(3+)染色。
根据新闻稿，Emrelis是获批用于治疗高c-Met蛋白过度表达的经治晚期NSCLC患者的首款疗法。该类患者通常预后较差，治疗选择有限。
Teliso-V是一款靶向c-Met的ADC，以微管蛋白抑制剂MMAE作为毒性有效载荷。c-Met是一种在包括NSCLC在内的多种肿瘤中过度表达的受体酪氨酸激酶。该疗法在2022年1月获FDA突破性疗法认定，治疗非小细胞肺癌。
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