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　　加科思-B（01167）早盘股价上涨5.63%，现报3.94港元，成交额273.60万港元。

　　加科思-B发布公告，公司自主研发的SHP2抑制剂sitneprotafib （JAB-3312）相关研究见刊Clinical Cancer Research（《临床肿瘤研究》）。文章公布了SHP2抑制剂与PD-1抗体以及靶向RTK/RAS/MAPK通路的联合疗法中的临床前体内外数据和对联合疗法有回应的代表性患者病例。

　　研究表明sitneprotafib显著增强了KRAS G12C抑制剂戈来雷塞在未接受治疗和耐药模型中的抗肿瘤活性。Sitneprotafib与MEK抑制剂联合用药可显著延缓RTK信号的再启动，并增强KRAS突变癌症模型中的肿瘤生长抑制。Sitneprotafib与奥希替尼联合用药在奥希替尼耐药的非小细胞肺癌（NSCLC）模型中表现出优异的疗效。此外，sitneprotafib通过促进抗肿瘤微环境增强了PD-1抗体的疗效。

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