Wall Street's main indexes slipped and government bond yields rose on Wednesday, as investors closely watched a pivotal debate over U.S. President Donald Trump's tax-cut bill that has fanned concerns about the country's growing debt. .N

At 11:30 EDT, the Dow Jones Industrial Average .DJI was down 0.77% at 42,350.68. The S&P 500 .SPX was down 0.16% at 5,930.68, and the Nasdaq Composite .IXIC was up 0.35% at 19,210.09.

The top two S&P 500 .PG.INX percentage gainers:

** Alphabet Inc GOOGL.OQ, up 5.1%

** Keysight Technologies Inc KEYS.N, up 4.1%

The top three S&P 500 .PL.INX percentage losers:

** Fair Isaac Corp FICO.N, down 16.1%

** Palo Alto Networks Inc PANW.OQ, down 5.9%

** Phillips 66 PSX.N, down 5.7%

The top three NYSE .PG.N percentage gainers:

** Canada Goose Holdings Inc GOOS.N, up 27.5%

** Dycom Industries Inc DY.N, up 17.6%

** Xpeng Inc XPEV.N, up 13.0%

The top three NYSE .PL.N percentage losers:

** Wolfspeed Inc WOLF.N, down 68.8%

** Guardian Pharmacy Services Inc GRDN.N, down 17.9%

** Fair Isaac Corp FICO.N, down 16.1%

The top three Nasdaq .PG.O percentage gainers:

** SigmaTron International Inc SGMA.OQ, up 130.2%

** CFSB Bancorp Inc CFSB.OQ, up 73.3%

** Aptevo Therapeutics Inc APVO.OQ, up 72.9%

The top three Nasdaq .PL.O percentage losers:

** Petros Pharmaceuticals Inc PTPI.OQ, down 43.1%

** LeddarTech Holdings Inc. LDTC.OQ, down 36.2%

** Siyata Mobile Inc SYTA.OQ, down 33.9%

** Nu Holdings Ltd <NU.N>:BUZZ - Shares of Nubank parent slip as Youssef Lahrech steps down as president, COO nL4N3RT0KG

** Baidu Inc <BIDU.O>:BUZZ - US-listed shares rise on upbeat Q1 revenue nL4N3RT0MV

** Bilibili Inc <BILI.O>:BUZZ - Falls on planned $500 million convertible bond offering nL6N3RT0FY

** WeRide Inc <WRD.O>:BUZZ - Jumps after announcing $100 mln share buyback plan nL4N3RT0ON

** Modine Manufacturing Co <MOD.N>:BUZZ - Rises after Q4 revenue beats estimates nL4N3RT0OY

** Medtronic PLC <MDT.N>:BUZZ - Falls as co to separate diabetes business nL4N3RT0YG

** Take-Two Interactive Software Inc <TTWO.O>:BUZZ - Falls after $1 billion equity raise nL6N3RT0GA

** Lowe's Companies Inc <LOW.N>:BUZZ - Gains on smaller-than-expected drop in comparable sales nL4N3RT0RD

** XPeng Inc <XPEV.N>:BUZZ - US-listed shares rise on strong Q2 revenue forecast nL4N3RT0RJ

** Toll Brothers Inc <TOL.N>:BUZZ - Jumps after Q2 earnings tops estimates nL4N3RT0QJ

** Target Corp <TGT.N>:BUZZ - Falls after cutting annual forecasts on tariff pressures, sluggish demand nL4N3RT0TI

** UnitedHealth Group Inc <UNH.N>:BUZZ - Pares losses on saying allegations in media report known, found inaccurate by US DOJ nL4N3RT10H

** Centuri Holdings Inc <CTRI.N>:BUZZ - Falls after pricing of secondary offering nL6N3RT0H9

** TPG Inc <TPG.O>:BUZZ - Falls after $992 million secondary offering nL4N3RN1FU

** Deere & Co <DE.N>:BUZZ - BMO raises Deere PT on better 2026 profit forecast nL4N3RT0WL

** Moderna Inc <MRNA.O>:BUZZ - Falls after co withdraws application for COVID-flu combination vaccine nL6N3RT0IU

** CFSB Bancorp Inc <CFSB.O>:BUZZ - Soars on $44 mln buyout offer from Hometown Financial nL4N3RS0Y5

** Keysight Technologies <KEYS.N>:BUZZ - Rises after Q2 earnings top estimates nL4N3RT0ZW

** Phillips 66 <PSX.N>:BUZZ - Falls after split result in proxy fight with Elliott nL4N3RT13M

** Garrett Motion Inc <GTX.O>:BUZZ - Falls as top shareholders look to cut stake in secondary offering nL4N3RT10P

** Palo Alto Networks Inc <PANW.O>:BUZZ - Slips after Q3 operating expenses rise nL4N3RT119

** B Riley Financial Inc <RILY.O>:BUZZ - Hits one-month high on deal to reduce debt nL4N3RT174

** Guardian Pharmacy Services Inc <GRDN.N>:BUZZ - Slides as shareholders look to cut stake in secondary offering nL4N3RT16Y

** AutoZone Inc <AZO.N>:BUZZ - BofA upgrades AutoZone to 'buy', raises PO nL4N3RT17I

** Dycom Industries Inc <DY.N>:BUZZ - Jumps to record high on Q1 profit beat, higher revenue forecast nL6N3RT0PB

(Compiled by Rajarshi Roy and Sneha S K)

((Rajarshi.Roy@thomsonreuters.com))