智通财经APP获悉，加科思-B(01167)涨超6%，截至发稿，涨5.92%，报4.65港元，成交额949.93万港元。
消息面上，近日，加科思-B发布公告，根据国家药品监督管理局官方网站信息，公司自主研发的KRAS G12C抑制剂艾瑞凯®(通用名：戈来雷塞)正式获批上市。适应症为至少经历过一种系统性治疗的KRAS G12C突变的非小细胞肺癌。此次获批触发里程碑付款条件，加科思将收到来自合作伙伴上海艾力斯医药科技股份有限公司(688578.SH)5,000万元里程碑付款。
艾瑞凯®获得批准上市，是基于一项在中国开展的二期注册性临床试验，该试验的完整数据已刊登在《Nature Medicine》(影响因子58.7)。基于戈来雷塞关键性II期单臂研究的积极结果，在单药二线及以上非小细胞肺癌患者中，戈来雷塞客观缓解率(ORR)为49.6%，疾病控制率(DCR)达86.3%，中位无进展生存期(PFS)达8.2个月，中位总生存期(OS)达17.5个月。从安全性数据显示，戈来雷塞有良好的安全性特征，和其他KRAS G12C抑制剂相比，具有良好的消化道安全性特征。加科思已将艾瑞凯®的中国(包括中国内地、中国香港、中国澳门和中国台湾省)权益授权授予艾力斯。
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