强生公司公布，根据2025年欧洲血液学协会（EHA）大会上报告的间接比较分析（MAIC）结果，在一线治疗慢性淋巴细胞白血病（CLL）中，伊布替尼（Imbruvica，亿珂®）联合维奈托克（venetoclax）的疗效优于阿卡替尼（acalabrutinib）联合维奈托克方案。

　　伊布替尼是全球获批的首个BTK抑制剂。

　　强生公布的试验数据显示，I+V方案（即伊布替尼+维奈托克）相比A+V方案（即阿卡替尼+维奈托克）可降低47%的疾病进展或死亡风险，并在治疗三个月后实现更高比例的微小残留病灶阴性（uMRD）反应。

　　一项II期研究的最终结果证实了I+V方案的长期临床获益：5.5年无进展生存率和总生存率分别达到66%和97%。

　　研究显示患者复发率为32%，且未出现BTK或PLCG2耐药突变。未观察到新的安全性信号。强生强调，作为固定口服方案中随访时间最长的验证方案，伊布替尼为CLL患者树立了新的治疗标准。

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