本周观点本周,我们梳理了肿瘤免疫靶点CD73 的作用机制和在研产品,重点关注全球进度领先的小分子抑制剂和单抗。CD73 是极具潜力的肿瘤免疫治疗靶点。腺苷在多种疾病中具有免疫抑制作用,CD73 是催化细胞外腺苷生成的限速酶。CD73 在调节性T 细胞、B 细胞、巨噬细胞和自然杀伤细胞等多种免疫细胞中发挥重要的肿瘤免疫调节作用。肿瘤微环境(TME)是一个高度动态的环境,存在多种免疫抑制机制,从而使...
Source Link本周观点本周,我们梳理了肿瘤免疫靶点CD73 的作用机制和在研产品,重点关注全球进度领先的小分子抑制剂和单抗。CD73 是极具潜力的肿瘤免疫治疗靶点。腺苷在多种疾病中具有免疫抑制作用,CD73 是催化细胞外腺苷生成的限速酶。CD73 在调节性T 细胞、B 细胞、巨噬细胞和自然杀伤细胞等多种免疫细胞中发挥重要的肿瘤免疫调节作用。肿瘤微环境(TME)是一个高度动态的环境,存在多种免疫抑制机制,从而使...
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