European equities traded in the US as American depositary receipts were tracking lower late Wednesday morning, falling 0.84% to 1,466.92 on the S&P Europe Select ADR Index.

From continental Europe, the gainers were led by biopharmaceutical company DBV Technologies (DBVT) and medical device maker EDAP TMS (EDAP), which rose 4.4% and 2.9% respectively. They were followed by internet browser company Opera (OPRA) and oil and gas company TotalEnergies (TTE), which were up 1.1% and 0.9%.

The decliners from continental Europe were led by semiconductor company Sequans Communications (SQNS) and pharmaceutical company Ascendis Pharma (ASND), which lost 6.5% and 4.4% respectively. They were followed by pharmaceutical company Novo Nordisk (NVO) and Spanish lender Banco Bilbao Vizcaya Argentaria (BBVA), which dropped 4.2% and 3.5%.

From the UK and Ireland, the gainers were led by biopharmaceutical companies Amarin (AMRN) and Mereo BioPharma Group (MREO), which increased 4% and 1.8% respectively. They were followed by insurance firm Prudential (PUK) and lender HSBC (HSBC), which edged 0.6% and 0.4% higher respectively.

The decliners from the UK and Ireland were led by biopharmaceutical company Adaptimmune Therapeutics (ADAP) and biotech firm Autolus Therapeutics (AUTL), which lost 3.3% and 3.1% respectively. They were followed by communications company WPP (WPP) and biotech firm Trinity Biotech (TRIB), which shed 3% and 2.6% respectively.