iza-bren(BL-B01D1)是百利天恒自主研发的EGFR×HER3 双抗ADC。iza-bren 由EGFR×HER3 双特异性抗体组成,通过可裂解连接子连接至新型TOP-1 抑制剂Ed-04。DAR 为8。iza-bren 与在肿瘤细胞上共表达的EGFR 及HER3 结合来缓解抗药性,喜树硷类衍生物Ed-04 被内化并转运至溶酶体释放促使细胞凋亡。iza-bren 正在中美进行约30 项...
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