Top Midday Decliners

MT Newswires Live

Jul 11, 2025

Ultragenyx Pharmaceutical (RARE) shares dropped 26% after a phase 3 study update of UX143 missed a key efficacy metric in pediatric and young adult patients with osteogenesis imperfecta, a rare genetic bone disorder.

"Investors were disappointed" that the annualized fracture rate efficacy hurdle wasn't met, Wedbush Securities said Thursday in a report. UX143 is being developed in collaboration with Mereo BioPharma (MREO).

More than 10 million shares of Ultragenyx traded intraday compared with a daily average of about 1.07 million. Mereo sank 41% following an increase in intraday trading volume to over 25 million from a daily average of about 1.41 million.

Methode Electronics (MEI) late Wednesday reported a wider adjusted net loss and declining net sales in fiscal Q4.

Shares slumped 25% as intraday trading volume surged to more than 1.2 million from a daily average of roughly 291,000.

Helen of Troy (HELE) shares sank Thursday after the consumer products firm issued a downbeat Q2 outlook amid uncertainty around tariffs, which dented Q1 revenue by more than expected.

Shares slid 22%, with intraday trading volume at over 3.72 million, versus the stock's daily average of about 741,000.

Price: 30.50, Change: -10.94, Percent Change: -26.40

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UX143 is being developed in collaboration with Mereo BioPharma (MREO).</p><p>More than 10 million shares of Ultragenyx traded intraday compared with a daily average of about 1.07 million. 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UX143 is being developed in collaboration with Mereo BioPharma (MREO).</p><p>More than 10 million shares of Ultragenyx traded intraday compared with a daily average of about 1.07 million. 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Mereo sank 41% following an increase in intraday trading volume to over 25 million from a daily average of about 1.41 million.Methode Electronics (MEI) late Wednesday reported a wider adjusted net loss and declining net sales in fiscal Q4.Shares slumped 25% as intraday trading volume surged to more than 1.2 million from a daily average of roughly 291,000.Helen of Troy (HELE) shares sank Thursday after the consumer products firm issued a downbeat Q2 outlook amid uncertainty around tariffs, which dented Q1 revenue by more than expected.Shares slid 22%, with intraday trading volume at over 3.72 million, versus the stock's daily average of about 741,000.Price: 30.50, Change: -10.94, Percent Change: -26.40","kind":"highlight","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"0","news_tag":"","news_rank":0,"symbols":[],"gpt_button":0,"need_auth":false,"code":"91000000","status":"200"}}}