智通财经APP讯，海普瑞(002399.SZ)公告，公司自主研发的创新候选药物注射用H1710(简称“H1710”)I期临床试验已完成首例受试者入组及首次给药。
公告显示，注射用H1710是一种低抗凝活性的肝素衍生物，是海普瑞自主研发的高效高选择性的乙酰肝素酶(HPA)抑制剂。乙酰肝素酶在多种恶性肿瘤中高表达，并且与肿瘤的生长和转移密切相关。H1710通过抑制乙酰肝素酶的活性和表达，展现出抗肿瘤作用。H1710作为靶向乙酰肝素酶的全新化合物，具有更为合理的链长和独特的柔性结构，是一种高效、高选择性的乙酰肝素酶抑制剂。
本次临床试验为开放、剂量递增的Ia期临床研究，评价H1710在晚期实体瘤患者中的安全性、耐受性和初步抗肿瘤活性，为H1710的首次人体(FIH)试验，计划在三家研究中心开展，预计入组约36名患者。
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