中邮证券研报指出，广生堂乙肝创新药布局领先，临床治愈前景广阔。公司乙肝治疗一类创新药奈瑞可韦GST-HG141为新型乙肝核心蛋白/核衣壳调节剂，属于全新机制的乙肝病毒一类新药，为全球首个进入III期的新型乙肝核心蛋白变构调制剂，为我国突破性治疗品种。前期研究结果显示，GST-HG141片在核苷类药物治疗基础上对HBVDNA具有进一步显著优势的抑制效果，且明显降低HBVpgRNA，间接体现了对HBVcccDNA的潜在有效抑制和耗竭作用。目前，GST-HG141用于慢性乙型肝炎抗病毒药物应答不佳患者联合治疗的多中心III期临床试验已完成首例受试者入组，治疗周期48周，主要终点为血清HBVDNA低于20IU/mL的受试者百分比。我国慢乙肝患者2000-3000万人，根据服药年限及个体不同，约有10-45%的患者现有核苷类似药治疗应答不佳，GST-HG141销售前景广阔。首次推荐，给予“买入”评级。
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