又一款镇痛药临床失败

药智网
Aug 05

图1 主要疗效结果图片来源:福泰制药VX-993是一种选择性钠离子通道Nav1.8抑制剂。Nav1.8在外周感觉神经元中高度表达,与痛觉信号的传导密切相关,是一个备受关注的镇痛药物靶点。由于Nav1.8不参与中枢神经系统的生理活动,针对该靶点的抑制剂有望避免传统阿片类镇痛药的成瘾性和中枢神经系统副作用等问题。此前,福泰制药在镇痛领域已有一定的成果,如VX-548的成功上市,让市场对同为Nav1.8...

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