The most-talked-about stocks in the Reddit subforum Wallstreetbets were mixed hours before Monday's opening bell.

Opendoor Technologies (OPEN) was up 5% in pre-bell activity, after closing Friday with a 4.3% increase.

Novo Nordisk (NVO) rose by 4.2% in premarket hours, following a 2.9% increase at Friday's close. Novo Nordisk said the US Food and Drug Administration approved a new indication for semaglutide to treat adults with metabolic-dysfunction-associated steatohepatitis with moderate to advanced liver fibrosis, without cirrhosis.

UnitedHealth Group (UNH) advanced by 2.8% pre-bell, after a 12% increase from the previous session.

Webull (BULL) was 1.1% higher premarket, following a 3.6% rise from the previous session.

DTE Energy (DTE) was up 0.6% pre-bell, after a 0.7% decline from Friday's session

Intel (INTC) declined by 1.3% hours before market open, swinging from a 2.9% increase at Friday's close.

Nvidia (NVDA) was down 0.4% pre-bell, after a 0.9% decline at Friday's close.

Reddit (RDDT) was 0.2% lower premarket, swinging from a 1.2% increase at Friday's close.