Hepatology | 上海交通大学范广建等团队发现肝纤维化新机制YB-1GLI2通路激活星状细胞

iNature
Aug 20, 2025

iNature新兴证据表明,导管反应性细胞(ductular reactive cells, DRCs)介导的导管反应(ductular reaction, DR)能够加速肝星状细胞(hepatic stellate cells, HSCs)的活化,并促进肝纤维化的发生。先前研究提示,Y-box结合蛋白1(YB-1)可能参与促进DRC增殖。2025年7月,上海交通大学范广建,陆伦根和Fei Li...

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