默沙东(MRK.US)口服PCSK9第三项III期研究成功

智通财经
Sep 03, 2025

智通财经APP获悉,9月2日,默沙东(MRK.US)宣布Enlicitide治疗高胆固醇血症的III期CORALreef Lipids研究取得了积极结果。该研究是Enlicitide目前已完成的最大规模的III期研究。此前,该药物已顺利完成两项III期研究。

Enlicitide(MK-0616)是默沙东开发的一款口服环肽类PCSK9抑制剂。PCSK9(前蛋白转化酶枯草溶菌素9)主要在肝脏表达,是“坏胆固醇”LDL-C升高的帮凶。PCSK9可与肝细胞表面负责清除LDL-C的受体结合,导致大部分LDL-C无法被吸收。

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