恒瑞医药公告,公司及子公司福建盛迪医药有限公司收到国家药监局核准签发关于HRS-4729注射液的《药物临床试验批准通知书》,将于近期开展临床试验。HRS-4729注射液是公司自主研发的多肽类药物,是一种胰高血糖素样肽-1受体(GLP-1R)/葡萄糖依赖性促胰岛素多肽受体(GIPR)/胰高血糖素受体(GCGR)三激动剂。与GLP-1R/GIPR双靶点相比,三重受体激动剂通过在体内调节糖脂代谢、抑制食欲的基础上增加GCGR靶点激活活性,促进能量消耗、脂肪酸氧化、脂质分解,从而更好地发挥减重和减少肝脏脂肪效果。
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