IGC Pharma Announces Promising Preclinical Results for TGR-63, a Dual-Acting Alzheimer's Drug Targeting Beta-Amyloid and Tau Pathology
Reuters
Sep 24
IGC Pharma Announces Promising Preclinical Results for TGR-63, a Dual-Acting Alzheimer's Drug Targeting Beta-Amyloid and Tau Pathology
IGC Pharma Inc. (NYSE American: IGC) has announced new preclinical data on TGR-63, its investigational small-molecule candidate for Alzheimer's disease. The results demonstrate that TGR-63 inhibits both beta-amyloid and tau protein aggregation, addressing two key pathological features of Alzheimer's. In vitro assays showed that TGR-63 suppresses tau fibril formation at micromolar concentrations, and previous findings indicated its effectiveness in disrupting beta-amyloid plaque aggregation. Serum stability studies confirmed that TGR-63 maintains its structural integrity under physiological conditions and remains detectable in serum samples up to 24 hours post-administration. These preclinical findings have been presented by the company, and further development of TGR-63 is planned to advance it as a potential disease-modifying therapy for Alzheimer's disease.
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