宜明昂科-B(01541):IMM0306治疗滤泡性淋巴瘤的III期临床试验申请

智通财经
Sep 29

智通财经APP讯,宜明昂科-B(01541)发布公告,本集团已向中国国家药品监督管理局(国家药监局)药品审评中心提交IMM0306 III期临床试验的申请。

由本集团独立研发的IMM0306是一种靶向分化簇47(CD47)及分化簇20(CD20)的双特异性分子,是全球首个进入临床阶段的CD47和CD20双靶向双特异性分子。 IMM0306透过抑制CD47-SIRPα相互作用来阻断“别吃我”讯号,增强Fc-FcɣRIIa 和Fc-FcɣRIIIa相互作用来激活巨噬细胞和NK细胞,并优先结合CD20而非CD47,以有效消除恶性B细胞,同时将毒性降至最低,从而可改善治疗效果。

截至本公告日期,本集团拥有IMM0306的全球知识产权及商业化权利。

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