全球首创双靶点ADC!康宁杰瑞JSKN022获批临床,针对晚期实体肿瘤

药时空
Oct 11, 2025

2025年10月11日,据国家药品监督管理局药品审评中心(CDE)显示,江苏康宁杰瑞生物制药有限公司的注射用JSKN022获临床试验默示许可,适应症为晚期实体肿瘤。JSKN022是康宁杰瑞基于糖基定点偶联平台开发的创新双抗ADC药物,可同时识别并结合肿瘤细胞表面的PD-L1与αvβ6整合素。药物与任一靶点结合后通过靶点介导的内吞作用进入到溶酶体中,可切割的连接子在组织蛋白酶B等蛋白水解酶的作用下...

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