港股异动 | 宜明昂科-B(01541)涨超5% Treg细胞疗法备受关注目前公司正积极推进泰泽苏拜单抗临床开发

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智通财经APP获悉，宜明昂科-B(01541)涨超5%，截至发稿，涨5.22%，报11.47港元，成交额4047.65万港元。

消息面上，据宜明昂科-B官微消息，近日，玛丽·E·布伦科等三位科学家被授予2025年诺贝尔生理学或医学奖，以表彰他们在外周免疫耐受机制领域的研究成果。这一创新性研究成果找到了免疫系统的抑制开关，为全球数亿自身免疫病及癌症患者带来颠覆性疗法。调节性T细胞(Treg 细胞)通过Foxp3转录因子维持免疫耐受，其功能异常与自身免疫病、癌症等密切相关，而细胞毒性T淋巴细胞相关抗原4(CTLA-4)是Treg细胞执行免疫抑制功能的“关键效应分子”。Treg细胞的发现及其作用机制研究，为开发新一代免疫调节药物提供了理论基础。

据介绍，宜明昂科开发的新一代CTLA-4抗体泰泽苏拜单抗(tazlestobart，IMM27M)通过清除肿瘤微环境中的Treg细胞而发挥抗肿瘤疗效。目前宜明昂科正积极推进泰泽苏拜单抗的临床开发。泰泽苏拜单抗(tazlestobart，IMM27M)是宜明昂科公司自主研发的新一代CTLA-4抗体，通过基因工程技术加强了ADCC活性，可以全面清除肿瘤微环境中的Treg细胞。IMM27M是一种针对Treg细胞的创新药物，其主要作用机制是通过靶向Treg细胞上的特定分子CTLA-4，调节其功能或数量，从而增强免疫反应。

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The company is currently actively promoting the clinical development of Taizesubimab","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"01541":1.5},"content_text":"智通财经APP获悉，宜明昂科-B(01541)涨超5%，截至发稿，涨5.22%，报11.47港元，成交额4047.65万港元。消息面上，据宜明昂科-B官微消息，近日，玛丽·E·布伦科等三位科学家被授予2025年诺贝尔生理学或医学奖，以表彰他们在外周免疫耐受机制领域的研究成果。这一创新性研究成果找到了免疫系统的抑制开关，为全球数亿自身免疫病及癌症患者带来颠覆性疗法。调节性T细胞(Treg 细胞)通过Foxp3转录因子维持免疫耐受，其功能异常与自身免疫病、癌症等密切相关，而细胞毒性T淋巴细胞相关抗原4(CTLA-4)是Treg细胞执行免疫抑制功能的“关键效应分子”。Treg细胞的发现及其作用机制研究，为开发新一代免疫调节药物提供了理论基础。据介绍，宜明昂科开发的新一代CTLA-4抗体泰泽苏拜单抗(tazlestobart，IMM27M)通过清除肿瘤微环境中的Treg细胞而发挥抗肿瘤疗效。目前宜明昂科正积极推进泰泽苏拜单抗的临床开发。泰泽苏拜单抗(tazlestobart，IMM27M)是宜明昂科公司自主研发的新一代CTLA-4抗体，通过基因工程技术加强了ADCC活性，可以全面清除肿瘤微环境中的Treg细胞。IMM27M是一种针对Treg细胞的创新药物，其主要作用机制是通过靶向Treg细胞上的特定分子CTLA-4，调节其功能或数量，从而增强免疫反应。","kind":"news","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"1","news_tag":"productRelease","news_rank":0,"symbols":[],"gpt_button":1,"need_auth":false,"code":"91000000","status":"200"}}}