智通财经APP获悉，Intellia Therapeutics公司(NTLA.US)在暂停两项nexiguran ziclumeran(简称nex-z)三期临床试验的给药后，其股价于周一交易中一度暴跌47.6%，收跌42.23%。
此次暂停给药，源于MAGNITUDE试验中出现一例严重不良事件报告：一名患者因出现4级肝转氨酶升高及总胆红素升高而住院。该试验旨在评估nex-z用于治疗转甲状腺素蛋白淀粉样变性心肌病(ATTR-CM)的疗效与安全性。另一项暂停的试验为MAGNITUDE-2，其研究方向是转甲状腺素蛋白淀粉样变性多发性神经病(ATTR-PN)。
目前，这两项试验的患者入组工作也已暂停。
截至当前，MAGNITUDE试验已入组650名患者，MAGNITUDE-2试验已入组47名患者。据估算，已有超过450名患者接受过nex-z给药治疗。
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