Aldeyra Therapeutics Reports Positive Phase 2 Results for ADX-629 in Alcohol-Associated Hepatitis
Reuters
Oct 28
Aldeyra <a href="https://laohu8.com/S/LENZ">Therapeutics</a> Reports Positive Phase 2 Results for ADX-629 in Alcohol-Associated Hepatitis
Aldeyra Therapeutics Inc. announced positive results from a Phase 2 clinical trial evaluating ADX-629, an investigational RASP modulator, in patients with mild to moderate alcohol-associated hepatitis. The single-arm, multicenter study involved oral administration of ADX-629 for one month in four patients. Statistically significant improvements were observed in markers of hepatic function and inflammation, including the Model for End-Stage Liver Disease (MELD) score (P=0.001), triglyceride levels (P<0.0001), and C-Reactive Protein levels (P<0.0001). No serious adverse events were reported, and no adverse events were considered related to ADX-629. The company indicated that these positive results mark the culmination of clinical proof-of-concept for ADX-629, and that further details will be shared in the future. Aldeyra also announced a strategic shift in its pipeline to focus on next-generation RASP modulators, specifically ADX-248 and ADX-246, for the treatment of immune-mediated diseases.
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