智通财经APP获悉，10月28日，默沙东(MRK.US)宣布两则消息：1)评估双重口服疗法Welireg(贝组替凡)联合仑伐替尼用于治疗既往接受抗PD-1/L1疗法后疾病进展的晚期肾细胞癌患者的III期LITESPARK-011试验达到了其无进展生存期(PFS)的主要终点之一。贝组替凡是默沙东首创的口服缺氧诱导因子-2α(HIF-2α)抑制剂。
在预设的中期分析中，贝组替凡联合仑伐替尼与卡博替尼相比，在PFS方面表现出统计学显著且具有临床意义的改善。该联合疗法在试验的关键次要终点客观缓解率(ORR)方面，与卡博替尼相比也显示出统计学显著改善。
肾细胞癌(RCC)是最常见的肾癌类型，大约十分之九的肾癌诊断是 RCC。2022 年，全球约有 435,000 例肾癌新诊断病例，约 156,000 人死于该病。RCC 在男性中的发病率大约是女性的两倍。大多数肾细胞癌病例是在其他腹部疾病的影像学检查中偶然发现的。大约 30% 的肾癌患者被诊断为晚期。
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