HUTCHMED Unveils Promising ATTC Platform and Advances Lead Cancer Candidate HMPL-A251

Reuters

10 hours ago

HUTCHMED Unveils Promising ATTC Platform and Advances Lead Cancer Candidate HMPL-A251

HUTCHMED (China) Ltd. has announced advances in its research and development pipeline during its recent R&D Updates event. The company unveiled its next-generation Antibody-Targeted Therapy Conjugate (ATTC) platform, highlighting its potential to provide precision oncology solutions through a dual-mechanism of action. The lead candidate, HMPL-A251, utilizes a selective PI3K/PIKK inhibitor payload and has shown promising preclinical efficacy and safety in HER2-positive and HER2-low models, both with and without PAM alterations. HUTCHMED plans to initiate clinical development of HMPL-A251 starting in late 2025, with initial studies set to evaluate the candidate across various cancer types. These research results were presented during the October 31, 2025 event.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. HUTCHMED (China) Ltd. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9566496-en) on November 03, 2025, and is solely responsible for the information contained therein.

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While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. HUTCHMED (China) Ltd. published the original content used to generate this news brief via GlobeNewswire (Ref. 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The company unveiled its next-generation Antibody-Targeted Therapy Conjugate (ATTC) platform, highlighting its potential to provide precision oncology solutions through a dual-mechanism of action. The lead candidate, HMPL-A251, utilizes a selective PI3K/PIKK inhibitor payload and has shown promising preclinical efficacy and safety in HER2-positive and HER2-low models, both with and without PAM alterations. HUTCHMED plans to initiate clinical development of HMPL-A251 starting in late 2025, with initial studies set to evaluate the candidate across various cancer types. These research results were presented during the October 31, 2025 event.\n      \n\nDisclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. 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