LEAD™(Ligand and Enhancer Assisted Delivery,新型配体与增效基团协同递送)平台是圣因生物自主研发的一种组织选择性递送技术,能够实现RNAi药物在肝外组织与细胞中的高效、特异性递送。基于该平台,有望开发出每年仅需两次皮下给药的代谢性疾病突破性疗法。圣因生物将负责基于LEAD™平台为双方合作项目筛选并确定最优RNAi活性分子,礼来将负责后续药物的IND申报研究、临床开发和商业化。
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