维立志博-B(09887):LBL-024于一线治疗肝细胞癌II期试验的首例患者用药

智通财经
Nov 10

智通财经APP讯,维立志博-B(09887)发布公告,评价奥帕替苏米单抗(PD-L1/4-1BB双特异性抗体LBL-024)用于一线治疗肝细胞癌的II期临床研究首例患者已成功用药,标志着该核心产品适应症拓展高效推进。

本次开展的开放标签、多中心II期临床研究由复旦大学附属中山医院周俭教授牵头,正在全国多家医院同步推进。该试验旨在评价奥帕替苏米单抗联合用药一线治疗肝细胞癌患者的疗效及安全性。

LBL-024是一种同时靶向PD-L1与4-1BB的双特异性抗体,为针对肺外神经内分泌癌的全球首款达到注册临床阶段的靶向4-1BB受体的疗法。LBL-024亦有望成为治疗晚期肺外神经内分泌癌的首款获批药物。凭藉我们专有的X-body®平台, LBL-024采用最佳的2:2结构设计,可解除PD-1/L1免疫抑制并强化4-1BB调节的T 细胞激活,实现协同消灭肿瘤的效果,具有较PD-1/L1抑制剂更强的广谱癌症治疗潜力。

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