抑郁障碍是最常见的精神障碍之一,以持续的心境低落/快感缺失/精力下降为核心临床特征,病因尚不完全明确,存在单胺假说、谷氨酸能系统异常假说等多种假说。抑郁障碍全病程治疗分急性期、巩固期、维持期3个阶段,存在诸多尚未被满足的临床需求:1)SSRIs等现有一线抗抑郁药疗效有限,理论上仍有1/3的患者经多步序贯治疗后无法达到缓解。2)现有抗抑郁药起效慢,通常需要1-4周见到改善、4-8周达到预期治疗目标,...
Source Link抑郁障碍是最常见的精神障碍之一,以持续的心境低落/快感缺失/精力下降为核心临床特征,病因尚不完全明确,存在单胺假说、谷氨酸能系统异常假说等多种假说。抑郁障碍全病程治疗分急性期、巩固期、维持期3个阶段,存在诸多尚未被满足的临床需求:1)SSRIs等现有一线抗抑郁药疗效有限,理论上仍有1/3的患者经多步序贯治疗后无法达到缓解。2)现有抗抑郁药起效慢,通常需要1-4周见到改善、4-8周达到预期治疗目标,...
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