Wall Street's main indexes hit one-month lows on Tuesday on concerns over lofty equity valuations and dimming prospects of a December interest rate cut, while investors awaited Nvidia's earnings and key government data due later this week. .N

At 13:30 EST, the Dow Jones Industrial Average .DJI was down 0.68% at 46,275.46. The S&P 500 .SPX was down 0.33% at 6,649.58, and the Nasdaq Composite .IXIC was down 0.63% at 22,559.84.

The top three S&P 500 .PG.INX percentage gainers:

** Medtronic PLC MDT.N, up 5.8%

** Warner Bros Discovery Inc WBD.OQ, up 5.1%

** Freeport-McMoRan Inc FCX.N, up 4.9%

The top three S&P 500 .PL.INX percentage losers:

** Texas Pacific Land Corp TPL.N, down 5.3%

** Home Depot Inc HD.N, down 4.4%

** Western Digital Corp WDC.OQ, down 4.1%

The top three NYSE .PG.N percentage gainers:

** Annovis Bio Inc ANVS.N, up 19.1%

** Biohaven Ltd BHVN.N, up 15.4%

** Sos Ltd SOS.N, up 12.6%

The top three NYSE .PL.N percentage losers:

** Energizer Holdings Inc ENR.N, down 17.2%

** Cango Inc CANG.N, down 10.4%

** Trinseo PLC TSE.N, down 8.8%

The top three Nasdaq .PG.O percentage gainers:

** Olema Pharmaceuticals Inc OLMA.OQ, up 142.3%

** Epsium Enterprise Ltd EPSM.OQ, up 60.6%

** Leifras Co Ltd LFS.OQ, up 58.8%

The top three Nasdaq .PL.O percentage losers:

** Trugolf Holdings Inc TRUG.OQ, down 34.0%

** Inspire Veterinary Partners Inc IVP.OQ, down 33.6%

** Zynex Inc ZYXI.OQ, down 28.3%

** Vanda Pharmaceuticals Inc VNDA.O:BUZZ - Set for best day in over five months as nausea drug shows promise for GLP-1 side effects nL6N3WU0W1

** Home Depot Inc HD.N:BUZZ - Falls after annual profit target cut nL6N3WU0U3

** Coinbase Global Inc COIN.O:

** Robinhood Markets Inc HOOD.O:

** Strategy Inc MSTR.O:

** Riot Platforms Inc RIOT.O:

BUZZ - Crypto stocks dip as bitcoin hits near 7-month low nL6N3WT0I2

** Archer Aviation Inc ACHR.N:BUZZ - Rises on electric powertrain supply deal nL4N3WU0M5

** Axalta Coating Systems Inc AXTA.N:BUZZ - Rises on merger plan with Akzo Nobel to create $25 bln paint giant nL4N3WU0N1

** PDD Holdings Inc PDD.O:BUZZ - US-listed shares fall after Q3 revenue misses estimates nL6N3WU0Y1

** DuPont DE Neumors Inc DD.N:BUZZ - RBC cuts DuPont PT to reflect Qnity spinoff; maintains 'outperform' rating nL6N3WU0NE

** D Market Elektronik Hizmetler ve Ticaret AS HEPS.O:BUZZ - J.P. Morgan downgrades Hepsiburada, says rising costs to pressure profits nL6N3WU0N5

** Meta Platforms Inc META.O:BUZZ - Down; MoffettNathanson cuts PT on likely margin pressure from AI costs nL4N3WU0QX

** Amazon.com Inc AMZN.O:

** Microsoft Corp MSFT.O:BUZZ - Dip; EU probes AWS, Azure cloud services nL6N3WU0TW

** Medtronic PLC MDT.N:BUZZ - Set for best day in over three years on upbeat annual forecast nL6N3WU0U8

** Molina Healthcare Inc MOH.N:BUZZ - Rises after announcing $850 million bond sale nL4N3WU0S4

** Amer Sports Inc AS.N:BUZZ - Up after FY forecast raise, Q3 revenue beat nL4N3WU0Q4

** Blue Owl Capital Inc OWL.N:BUZZ - Slips after blocking redemptions from private credit fund nL6N3WU0PC

** Genprex Inc GNPX.O:BUZZ - Rises after winning US patent for cancer drug combination nL4N3WU0TI

** Cloudflare Inc NET.N:BUZZ - Falls on outage reports; Musk's X down for some users nL6N3WU0PH

** Deckers Outdoor Corp DECK.N:BUZZ - Strong growth outlook fuels Stifel to upgrade Deckers Outdoor to 'buy' nL6N3WU0PQ

** BellRing Brands Inc BRBR.N:BUZZ - Falls after forecasting FY net sales below Street estimate nL4N3WU0UY

** Invivyd Inc IVVD.O:BUZZ - Tumbles on $125 mln stock sale nL6N3WU0P4

** Canaan Inc CAN.O:BUZZ - Rises after quarterly revenue forecast above estimates nL6N3WU0QD

** Lumentum Holdings Inc LITE.O:BUZZ - Mizuho starts coverage on Lumentum with 'outperform' rating nL4N3WU0VY

** Legence Corp LGN.O:BUZZ - Jefferies upgrades Legence to 'buy', raises PT on strong Q3 nL6N3WU0QQ

** Ceva Inc CEVA.O:BUZZ - Slides after stock offering launched nL6N3WU0QV

** Freeport-McMoRan Inc FCX.N:BUZZ - Gains on plans to restore production at Indonesia's Grasberg mine nL6N3WU0R6

** Merck & Co Inc MRK.N:BUZZ - Rises after lung disease drug meets main goal in mid-stage study nL6N3WU0QF

** Diversified Energy Company PLC DEC.N:BUZZ - William Blair starts Diversified Energy's coverage with 'outperform' nL6N3WU0RP

** Ardent Health Inc ARDT.N:BUZZ - Rises on $50 million share buyback plan nL6N3WU0S4

** Intuit Inc INTU.O:BUZZ - Rises after announcing $100 million OpenAI partnership nL6N3WU0RG

** Boise Cascade Co BCC.N:BUZZ - Falls on deal to purchase Humphrey Company nL6N3WU0T8

** Galmed Pharmaceuticals Inc GLMD.O:BUZZ - Rises after positive results of liver drug formulation study nL4N3WU104

** Honeywell International Inc HON.O:BUZZ - Falls; BofA downgrades to 'underperform' nL6N3WU0V8

** Figure Technology Solutions Inc FIGR.O:BUZZ - Slides after unveiling blockchain stock offering nL6N3WU0WA

** StubHub Holdings Inc STUB.N:BUZZ - Falls as UK bans ticket resale for profit, competition regulator launches investigation into co nL4N3WU186

** OSI Systems Inc OSIS.O:BUZZ - Falls after convertible bond sale increased to $500 mln nL6N3WU0YX

** New Fortress Energy Inc NFE.O:

** Venture Global Inc VG.N:

** EQT Corp EQT.N:

** Expand Energy Corp EXE.O:

BUZZ - Natgas companies fall on milder weather forecasts, lower demand nL4N3WU1B1

** Kroger Co KR.N:BUZZ - Rises: eyes 2026 online profit improvement as it takes robotic warehouse charge nL6N3WU0YJ

** Kilroy Realty Corp KRC.N:BUZZ - Up after BMO upgrades to 'market perform' nL6N3WU0XI

** Arrowhead Pharmaceuticals Inc ARWR.O:BUZZ - Rises after genetic disorder drug gets US FDA nod nL4N3WU1AE

** Klarna Group PLC KLAR.N:BUZZ - Reports loss in first results since market debut, shares fall nL6N3WU0ZK

** American Integrity Insurance Group Inc AII.N:BUZZ - Eases as top investor, CEO to reduce stakes nL6N3WU122

** Warner Bros Discovery Inc WBD.O:BUZZ - Up after report on $71 billion bid by Paramount, Arab sovereign wealth funds nL4N3WU1H7

** Target Corp TGT.N:BUZZ - Seen posting y/y EPS, rev drop with shutdown weighing nL6N3WU12I

** Energizer Holdings ENR.N:

BUZZ - falls after co misses Q4 profit estimate nL4N3WU1IP

(Rajarshi Roy and Parth Chandna)

((Rajarshi.Roy@thomsonreuters.com))