Small U.S. Stocks End Mixed As SEMrush Holdings Leads, Agios Pharmaceuticals Lags

Dow Jones
3 hours ago

This article was automatically generated using Dow Jones technology.

Shares of small-cap companies were mixed Wednesday, as the Russell 2000 Index closed flat, and the S&P Small Cap 600 Index was down 0.1%.

Among companies with a market value of $1 billion to $6.7 billion, SEMrush Holdings Inc. was the best performer during the session, surging 74%, followed by Nuvation Bio Inc., which surged 49%. La-Z-Boy Inc. shares surged 20%, Amentum Holdings Inc. surged 17%, and shares of PACS Group Inc. surged 17%.

Agios Pharmaceuticals Inc. was the biggest laggard, dropping 51%, followed by shares of Diginex Ltd., which dropped 17%. Shares of Ramaco Resources Inc. Cl A dropped 13%, Precigen Inc. shares plunged 13%, and Powell Industries Inc. tumbled 11%.

Major stock indexes in the U.S. closed up Wednesday as the Nasdaq Composite Index gained 0.6%. Meanwhile, the S&P 500 Index added 0.4%, and the Dow Jones Industrial Average added 0.1%.

Data source: Dow Jones Market Data, FactSet

 

(END) Dow Jones Newswires

November 19, 2025 16:20 ET (21:20 GMT)

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