MiNK <a href="https://laohu8.com/S/LENZ">Therapeutics</a> Reports MiNK-215 Shows Strong Anti-Tumor Activity in Resistant Solid Tumors
MiNK Therapeutics Inc. has announced new preclinical research results for its novel therapy, MiNK-215, which targets solid tumors resistant to current immunotherapies. The findings, now published in Cancer Immunology Research, show that MiNK-215-an IL-15-enhanced, FAP-targeting CAR-iNKT cell therapy-can effectively dismantle tumor-protective fibroblast barriers, remodel the tumor microenvironment, and activate multiple immune pathways. In models of lung and microsatellite stable $(MSS)$ colorectal cancer, MiNK-215 promoted immune cell infiltration, activated dendritic cells, re-polarized macrophages, and enabled robust anti-tumor activity. As an off-the-shelf, allogeneic therapy, MiNK-215 offers a scalable treatment option for patients with solid tumors that have not responded to conventional immune-based therapies.
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