创新药双周报:4-1BB:复盘历史失败原因 维立志博做对了什么?

华福证券
Nov 23

4-1BB专题:4-1BB(又名CD137、TNFRSF9),是肿瘤坏死因子受体超家族的关键成员,广泛表达于多种免疫细胞,当T 细胞通过TCR 识别抗原(信号1)后,41BB 与配体4-1BBL 结合(信号2),能进一步激活免疫细胞,为免疫应答“加速”,开启抗肿瘤防御。第二代CAR-T细胞技术已被验证选择4-1BB CAR-T细胞诱导较慢但更持久的活化,使CAR-T细胞在体内具有更长的存活时间和...

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