Enlivex Reports Six-Month Data Showing Sustained Pain Relief With Allocetra in Knee Osteoarthritis

Reuters

Nov 24, 2025

Enlivex Reports Six-Month Data Showing Sustained Pain Relief With Allocetra in Knee Osteoarthritis

Enlivex Therapeutics Ltd. announced positive six-month topline data from the Phase IIa stage of its randomized, multi-country Phase I/II Allocetra™ trial (ENX-CL-05-001) in patients with moderate to severe knee osteoarthritis. The results, which have already been presented, indicate that Allocetra™ demonstrated substantial and durable reduction in pain and improvement in function across multiple efficacy endpoints in patients aged 60 and above, compared to placebo. The six-month data reaffirm findings reported at three months and show a robust positive correlation between patient age and the magnitude of clinical effect. Allocetra™ maintained a favorable safety profile through the six-month follow-up. Enlivex plans to initiate a Phase IIb trial evaluating Allocetra™ in age-related primary knee osteoarthritis in the first half of 2026.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Enlivex Therapeutics Ltd. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9590928-en) on November 24, 2025, and is solely responsible for the information contained therein.

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The results, which have already been presented, indicate that Allocetra™ demonstrated substantial and durable reduction in pain and improvement in function across multiple efficacy endpoints in patients aged 60 and above, compared to placebo. The six-month data reaffirm findings reported at three months and show a robust positive correlation between patient age and the magnitude of clinical effect. Allocetra™ maintained a favorable safety profile through the six-month follow-up. Enlivex plans to initiate a Phase IIb trial evaluating Allocetra™ in age-related primary knee osteoarthritis in the first half of 2026.\n      \n\nDisclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Enlivex Therapeutics Ltd. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9590928-en) on November 24, 2025, and is solely responsible for the information contained therein.","kind":"highlight","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"1","news_tag":"dataReport,express","news_rank":0,"symbols":[],"gpt_button":0,"need_auth":false,"code":"91000000","status":"200"}}}