Ascletis Unveils Potent Oral Triple Agonist ASC37 for Obesity Treatment

Reuters

Nov 30, 2025

Ascletis Unveils Potent Oral Triple Agonist ASC37 for Obesity Treatment

Ascletis Pharma Inc. has announced the selection of ASC37, its first oral GLP-1R/GIPR/GCGR triple peptide agonist, for clinical development. In preclinical studies, ASC37 demonstrated significantly greater in vitro potency-approximately 5-fold for GLP-1R, 4-fold for GIPR, and 4-fold for GCGR-compared to retatrutide. The company plans to submit an Investigational New Drug Application $(IND)$ for ASC37 oral tablets to the U.S. Food and Drug Administration in the second quarter of 2026. These research results have been announced in advance of a planned conference call scheduled for December 1, 2025.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Ascletis Pharma Inc. published the original content used to generate this news brief via IIS, the Issuer Information Service operated by the Hong Kong Stock Exchange (HKex) (Ref. ID: HKEX-EPS-20251130-11933721), on November 30, 2025, and is solely responsible for the information contained therein.

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Ascletis Pharma Inc. published the original content used to generate this news brief via IIS, the Issuer Information Service operated by the Hong Kong Stock Exchange (HKex) (Ref. ID: HKEX-EPS-20251130-11933721), on November 30, 2025, and is solely responsible for the information contained therein.</span></em>\n</div></body></html>\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"BK1161","symbol_name":"生物科技","start_time":0,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251130:nNDL7vq4Kn:1","article_id":"2587918957","we_media_id":"1032215980","thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2587918957","pubTimestamp":1764497096,"columns":[],"sourceInfo":null,"weMediaInfo":{"media_name":"Reuters","introduction":"Reuters.com brings you the latest news from around the world, covering breaking news in markets, business, politics, entertainment and technology","home_visible":1,"id":"1032215980","head_image":"https://community-static.tradeup.com/news/4567337cbdf294b657b1fa87c5488b48"},"summary":"Ascletis Pharma Inc. has announced the selection of ASC37, its first oral GLP-1R/GIPR/GCGR triple peptide agonist, for clinical development. 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Ascletis Pharma Inc. published the original content used to generate this news brief via IIS, the Iss","collect":0,"end_time":0,"defaultTopTitle":"","property":[],"viewcount":null,"language":"en","relate_stocks":{"BK1161":"生物科技","01672":"歌礼制药-B","BK1515":"抗疫概念","BK1574":"生物医药B类股"},"translate_title":"歌礼推出用于肥胖治疗的强效口服三联激动剂ASC37","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"01672":0.9},"content_text":"Ascletis Unveils Potent Oral Triple Agonist ASC37 for Obesity Treatment\n    \n\nAscletis Pharma Inc. has announced the selection of ASC37, its first oral GLP-1R/GIPR/GCGR triple peptide agonist, for clinical development. In preclinical studies, ASC37 demonstrated significantly greater in vitro potency-approximately 5-fold for GLP-1R, 4-fold for GIPR, and 4-fold for GCGR-compared to retatrutide. The company plans to submit an Investigational New Drug Application $(IND)$ for ASC37 oral tablets to the U.S. Food and Drug Administration in the second quarter of 2026. These research results have been announced in advance of a planned conference call scheduled for December 1, 2025.\n      \n\nDisclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Ascletis Pharma Inc. published the original content used to generate this news brief via IIS, the Issuer Information Service operated by the Hong Kong Stock Exchange (HKex) (Ref. ID: HKEX-EPS-20251130-11933721), on November 30, 2025, and is solely responsible for the information contained therein.","kind":"highlight","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"1","news_tag":"productRelease","news_rank":0,"symbols":[],"gpt_button":0,"need_auth":false,"code":"91000000","status":"200"}}}