Fennec Pharmaceuticals Reports Positive Results for PEDMARK in Japanese Pediatric Cancer Study

Reuters

Dec 02, 2025

Fennec Pharmaceuticals Reports Positive Results for PEDMARK in Japanese Pediatric Cancer Study

Fennec Pharmaceuticals Inc. has announced positive topline results from the investigator-initiated Phase 2/3 STS-J01 clinical trial of PEDMARK® (sodium thiosulfate injection) in Japan. The study enrolled 27 pediatric and adolescent patients with non-metastatic solid tumors and demonstrated a significant reduction in cisplatin-induced hearing loss, with hearing loss rates of 16-24% compared to historically reported rates of 56-63% in patients receiving cisplatin alone. No interference with cisplatin's antitumor activity was observed, as evidenced by an approximate 95% clinical response rate. PEDMARK® was well-tolerated, with no adverse events attributed to the drug. Full study results will be presented at a future scientific meeting and submitted for publication. Fennec plans to pursue registration of PEDMARK® in Japan and is exploring partnering or licensing opportunities in the region.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Fennec Pharmaceuticals Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9594831-en) on December 02, 2025, and is solely responsible for the information contained therein.

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The study enrolled 27 pediatric and adolescent patients with non-metastatic solid tumors and demonstrated a significant reduction in cisplatin-induced hearing loss, with hearing loss rates of 16-24% compared to historically reported rates of 56-63% in patients receiving cisplatin alone. No interference with cisplatin's antitumor activity was observed, as evidenced by an approximate 95% clinical response rate. PEDMARK® was well-tolerated, with no adverse events attributed to the drug. Full study results will be presented at a future scientific meeting and submitted for publication. Fennec plans to pursue registration of PEDMARK® in Japan and is exploring partnering or licensing opportunities in the region.\n      </p>\n</div><div xmlns:xsd=\"http://www.w3.org/2001/XMLSchema\" xmlns:xsi=\"http://www.w3.org/2001/XMLSchema-instance\">\n<em>Disclaimer: <span>This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Fennec Pharmaceuticals Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9594831-en) on December 02, 2025, and is solely responsible for the information contained therein.</span></em>\n</div></body></html>\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"FENC","symbol_name":"Fennec Pharmaceuticals Inc.","start_time":0,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251202:nNDL34D3Mr:1","article_id":"2588030983","we_media_id":"1032215980","thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2588030983","pubTimestamp":1764676876,"columns":[],"sourceInfo":null,"weMediaInfo":{"media_name":"Reuters","introduction":"Reuters.com brings you the latest news from around the world, covering breaking news in markets, business, politics, entertainment and technology","home_visible":1,"id":"1032215980","head_image":"https://community-static.tradeup.com/news/4567337cbdf294b657b1fa87c5488b48"},"summary":"Fennec Pharmaceuticals Inc. has announced positive topline results from the investigator-initiated Phase 2/3 STS-J01 clinical trial of PEDMARK  in Japan. The study enrolled 27 pediatric and adolescent patients with non-metastatic solid tumors and demonstrated a significant reduction in cisplatin-induced hearing loss, with hearing loss rates of 16-24% compared to historically reported rates of 56-63% in patients receiving cisplatin alone. No interference with cisplatin's antitumor activity was observed, as evidenced by an approximate 95% clinical response rate. PEDMARK was well-tolerated, with no adverse events attributed to the drug. Full study results will be presented at a future scientific meeting and submitted for publication. Fennec plans to pursue registration of PEDMARK in Japan and is exploring partnering or licensing opportunities in the region.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. 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The study enrolled 27 pediatric and adolescent patients with non-metastatic solid tumors and demonstrated a significant reduction in cisplatin-induced hearing loss, with hearing loss rates of 16-24% compared to historically reported rates of 56-63% in patients receiving cisplatin alone. No interference with cisplatin's antitumor activity was observed, as evidenced by an approximate 95% clinical response rate. PEDMARK® was well-tolerated, with no adverse events attributed to the drug. Full study results will be presented at a future scientific meeting and submitted for publication. Fennec plans to pursue registration of PEDMARK® in Japan and is exploring partnering or licensing opportunities in the region.\n      \n\nDisclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Fennec Pharmaceuticals Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9594831-en) on December 02, 2025, and is solely responsible for the information contained therein.","kind":"highlight","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"1","news_tag":"dataReport,express","news_rank":0,"symbols":[],"gpt_button":0,"need_auth":false,"code":"91000000","status":"200"}}}