Oncotelic Therapeutics Identifies Context-Dependent Biomarkers in Liver and Pancreatic Cancer

Reuters

Dec 15, 2025

Oncotelic <a href="https://laohu8.com/S/LENZ">Therapeutics</a> Identifies Context-Dependent Biomarkers in Liver and Pancreatic Cancer

Oncotelic Therapeutics Inc., in collaboration with the Brush and Key Foundation, has announced the publication of a peer-reviewed research article in the International Journal of Molecular Sciences. The study, titled "Comparative Tumor Microenvironment Analysis for HCC and PDAC Using KMplotter," presents a comprehensive analysis of two emerging biomarkers-DNMT3A and GMPS-in hepatocellular carcinoma $(HCC)$ and pancreatic ductal adenocarcinoma (PDAC). The research, which analyzed data from over 7,000 patients, found that the prognostic significance of these biomarkers is highly context-dependent, influenced by immune composition, metabolic state, and innate immune pathways within the tumor microenvironment. These findings have already been published and highlight the importance of considering tumor context when interpreting biomarkers for cancer prognosis and therapy.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Oncotelic Therapeutics Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: 9602143) on December 15, 2025, and is solely responsible for the information contained therein.

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The study, titled \"Comparative Tumor Microenvironment Analysis for HCC and PDAC Using KMplotter,\" presents a comprehensive analysis of two emerging biomarkers-DNMT3A and GMPS-in hepatocellular carcinoma <a href=\"https://laohu8.com/S/HCC\">$(HCC)$</a> and pancreatic ductal adenocarcinoma (PDAC). The research, which analyzed data from over 7,000 patients, found that the prognostic significance of these biomarkers is highly context-dependent, influenced by immune composition, metabolic state, and innate immune pathways within the tumor microenvironment. These findings have already been published and highlight the importance of considering tumor context when interpreting biomarkers for cancer prognosis and therapy.\n      </p>\n</div><div xmlns:xsd=\"http://www.w3.org/2001/XMLSchema\" xmlns:xsi=\"http://www.w3.org/2001/XMLSchema-instance\">\n<em>Disclaimer: <span>This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Oncotelic Therapeutics Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: 9602143) on December 15, 2025, and is solely responsible for the information contained therein.</span></em>\n</div></body></html>\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"BK4139","symbol_name":"生物科技","start_time":0,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251215:nNDL1xT0dv:1","article_id":"2591647414","we_media_id":"1032215980","thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2591647414","pubTimestamp":1765810845,"columns":[],"sourceInfo":null,"weMediaInfo":{"media_name":"Reuters","introduction":"Reuters.com brings you the latest news from around the world, covering breaking news in markets, business, politics, entertainment and technology","home_visible":1,"id":"1032215980","head_image":"https://community-static.tradeup.com/news/4567337cbdf294b657b1fa87c5488b48"},"summary":"Oncotelic Therapeutics Inc., in collaboration with the Brush and Key Foundation, has announced the publication of a peer-reviewed research article in the International Journal of Molecular Sciences. The study, titled \"Comparative Tumor Microenvironment Analysis for HCC and PDAC Using KMplotter,\" presents a comprehensive analysis of two emerging biomarkers-DNMT3A and GMPS-in hepatocellular carcinoma  and pancreatic ductal adenocarcinoma . The research, which analyzed data from over 7,000 patients, found that the prognostic significance of these biomarkers is highly context-dependent, influenced by immune composition, metabolic state, and innate immune pathways within the tumor microenvironment. These findings have already been published and highlight the importance of considering tumor context when interpreting biomarkers for cancer prognosis and therapy.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. 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The study, titled \"Comparative Tumor Microenvironment Analysis for HCC and PDAC Using KMplotter,\" presents a comprehensive analysis of two emerging biomarkers-DNMT3A and GMPS-in hepatocellular carcinoma $(HCC)$ and pancreatic ductal adenocarcinoma (PDAC). The research, which analyzed data from over 7,000 patients, found that the prognostic significance of these biomarkers is highly context-dependent, influenced by immune composition, metabolic state, and innate immune pathways within the tumor microenvironment. These findings have already been published and highlight the importance of considering tumor context when interpreting biomarkers for cancer prognosis and therapy.\n      \n\nDisclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. 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