智通财经APP获悉，诺诚健华(09969)涨超4%，截至发稿，涨3.87%，报13.69港元，成交额3791.38万港元。
消息面上，12月18日，据诺诚健华官微消息，公司宣布，自主研发的新型TYK2抑制剂soficitinib(ICP-332)治疗慢性自发性荨麻疹(CSU)获国家药品监督管理局(NMPA)药品审评中心(CDE)批准开展II/III期临床试验。
Soficitinib是诺诚健华自主研发的高效、高选择性的新型口服TYK2抑制剂，开发用于治疗多种T细胞相关的自身免疫性疾病，目前开发的适应症深度布局皮肤科这一广阔的市场，包括特应性皮炎、白癜风、结节性痒疹、荨麻疹等。TYK2作为Janus激酶(JAK)家族成员，是JAK-STAT信号通路的关键激酶，在炎症发病机制中扮演重要角色。Soficitinib通过阻断IL-4、IL-13、IL-31等驱动肥大细胞活化和炎症反应的细胞因子信号通路，从而减轻瘙痒和风团形成，改善CSU症状。
相关数据显示，全球约有5000万慢性自发性荨麻疹患者，预计到2029年将全球CSU市场将达30亿美元。
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