Werewolf Therapeutics Reports Promising Phase 1 Data for WTX-124 and WTX-330 in Advanced Cancer Trials

Reuters

Dec 18, 2025

Werewolf <a href="https://laohu8.com/S/LENZ">Therapeutics</a> Reports Promising Phase 1 Data for WTX-124 and WTX-330 in Advanced Cancer Trials

Werewolf Therapeutics Inc. announced updates on its pipeline, including new clinical data for its INDUKINE™ programs. Initial Phase 1b expansion arm data for WTX-124 showed a 30% overall response rate as a monotherapy in a defined subset of post-ICI advanced or metastatic cutaneous melanoma patients, with a favorable tolerability profile. Initial data from the ongoing Phase 1b/2 trial of WTX-330 demonstrated additional evidence of antitumor activity and a highly favorable tolerability profile. The company plans to provide an additional Phase 1/1b data update for WTX-124 and complete Part A of the Phase 1b/2 clinical trial for WTX-330 in the first half of 2026. Werewolf Therapeutics is also progressing its INDUCER™ T cell engager platform, with plans for two IND filings by mid-2027 for WTX-1011 and WTX-2022.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Werewolf Therapeutics Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9604461-en) on December 18, 2025, and is solely responsible for the information contained therein.

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Initial Phase 1b expansion arm data for WTX-124 showed a 30% overall response rate as a monotherapy in a defined subset of post-ICI advanced or metastatic cutaneous melanoma patients, with a favorable tolerability profile. Initial data from the ongoing Phase 1b/2 trial of WTX-330 demonstrated additional evidence of antitumor activity and a highly favorable tolerability profile. The company plans to provide an additional Phase 1/1b data update for WTX-124 and complete Part A of the Phase 1b/2 clinical trial for WTX-330 in the first half of 2026. Werewolf Therapeutics is also progressing its INDUCER™ T cell engager platform, with plans for two IND filings by mid-2027 for WTX-1011 and WTX-2022.\n      </p>\n</div><div xmlns:xsd=\"http://www.w3.org/2001/XMLSchema\" xmlns:xsi=\"http://www.w3.org/2001/XMLSchema-instance\">\n<i>Disclaimer: <span>This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Werewolf Therapeutics Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9604461-en) on December 18, 2025, and is solely responsible for the information contained therein.</span></i>\n</div></body></html>\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"LU0314104364.USD","symbol_name":"MANULIFE GF AMERICAN GROWTH \"AA\" (USD) INC","start_time":0,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251218:nNDL7Tg6Dz:1","article_id":"2592906823","we_media_id":"1032215980","thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2592906823","pubTimestamp":1766062852,"columns":[],"sourceInfo":null,"weMediaInfo":{"media_name":"Reuters","introduction":"Reuters.com brings you the latest news from around the world, covering breaking news in markets, business, politics, entertainment and technology","home_visible":1,"id":"1032215980","head_image":"https://community-static.tradeup.com/news/4567337cbdf294b657b1fa87c5488b48"},"summary":"Werewolf Therapeutics Inc. announced updates on its pipeline, including new clinical data for its INDUKINE programs. Initial Phase 1b expansion arm data for WTX-124 showed a 30% overall response rate as a monotherapy in a defined subset of post-ICI advanced or metastatic cutaneous melanoma patients, with a favorable tolerability profile. Initial data from the ongoing Phase 1b/2 trial of WTX-330 demonstrated additional evidence of antitumor activity and a highly favorable tolerability profile. The company plans to provide an additional Phase 1/1b data update for WTX-124 and complete Part A of the Phase 1b/2 clinical trial for WTX-330 in the first half of 2026. Werewolf Therapeutics is also progressing its INDUCER T cell engager platform, with plans for two IND filings by mid-2027 for WTX-1011 and WTX-2022.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. 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Initial Phase 1b expansion arm data for WTX-124 showed a 30% overall response rate as a monotherapy in a defined subset of post-ICI advanced or metastatic cutaneous melanoma patients, with a favorable tolerability profile. Initial data from the ongoing Phase 1b/2 trial of WTX-330 demonstrated additional evidence of antitumor activity and a highly favorable tolerability profile. The company plans to provide an additional Phase 1/1b data update for WTX-124 and complete Part A of the Phase 1b/2 clinical trial for WTX-330 in the first half of 2026. Werewolf Therapeutics is also progressing its INDUCER™ T cell engager platform, with plans for two IND filings by mid-2027 for WTX-1011 and WTX-2022.\n      \n\nDisclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. 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