智通财经APP获悉，周二，Alumis(ALMS.US)开盘飙升超154%，创历史新高，报20.60美元。消息面上，该公司宣布了其envudeucitinib三期ONWARD1和ONWARD2临床试验的积极顶线结果。Envudeucitinib是一种下一代高度选择性的口服酪氨酸激酶2(TYK2)抑制剂，针对中度至重度斑块状银屑病患者。
在ONWARD1和ONWARD2中，Envudeucitinib以高统计学显著性达到了所有主要和次要终点。在这些试验中，Envudeucitinib在第16周的银屑病面积和严重程度指数(PASI)75和静态医生整体评估(sPGA)0/1共同主要终点上，相对于安慰剂表现出更优的皮肤清除效果(p < 0.0001)。在ONWARD1和ONWARD2中平均来看，74%的患者达到PASI 75，59%的患者达到sPGA 0/1，随着时间推移反应加深。此外，两个试验之间共同主要终点的安慰剂校正响应率保持一致。
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