Rein Therapeutics Inc., a clinical-stage biotechnology company, has released a corporate presentation outlining its progress in developing therapies for orphan pulmonary and fibrosis indications. The company’s lead candidate, LTI-03, is being evaluated as a potential treatment for idiopathic pulmonary fibrosis (IPF), with Phase 2 clinical trials underway. According to the presentation, LTI-03 demonstrated a favorable safety profile in Phase 1 trials, with no identified safety issues at the highest tested dose. The therapy works through a dual mechanism aimed at promoting alveolar epithelial cell survival and inhibiting profibrotic signaling. Initial interim data from the Phase 2 trial is anticipated in the second half of 2026. Other pipeline programs include LTI-01 for loculated pleural effusions and additional candidates targeting multiple fibrotic and pulmonary conditions. You can access the full presentation through the link below.

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