Madrigal Pharmaceuticals Inc. announced that it has entered into a First Amendment to its Research, Development, and Commercialization Agreement with F. Hoffmann-La Roche Ltd and Hoffmann-La Roche Inc., effective January 29, 2026. Under the terms of the amendment, Madrigal Pharmaceuticals will have full and exclusive rights to control all patent term adjustments and extensions related to Rezdiffra, including those for patents owned by Roche and jointly owned with Roche. Additionally, the royalty payments to Roche based on net sales of Rezdiffra will not be reduced until the expiration of certain applicable patent term extensions.
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